Centre for BioMathematics Colloquia Series: 'Insights from mathematical models of spheroids for drug uptake & cancer spread'

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Register at: https://swanseauniversity.zoom.us/meeting/register/tJYkd-uprz0jGdKrH2iz3Kg2JyuGvRGY-7bh


Prof Rachel Bearon (Department of Mathematical Sciences, University of Liverpool, UK)

From: 1 Dec 2021, 4 p.m.
To: 1 Dec 2021, 5 p.m.
Location: Online Event only for this Colloquium! Attendees must register for Zoom here: https://swanseauniversity.zoom.us/meeting/register/tJYkd-uprz0jGdKrH2iz3Kg2JyuGvRGY-7bh, Online Event - Please see description

Mathematical models can aid discovery in the life sciences, by providing predictive tools, and allowing efficient testing of ‘what-if’ scenarios. However, identifying the ‘right’ model, and suitably parameterizing it, is a challenging task which mathematicians are well-placed to contribute. I will discuss two projects based upon an experiments on 3D spheroid cell culture systems [1,2]. Cells cultured in such system have been shown to more closely resemble the functionality and morphology of cells in-vivo, and so there is increasing interest in using these systems for example in drug toxicity studies and for better understanding cancer metastasis.

[1] Leedale, J. A., Kyffin, J., Harding, A., Colley, H., Murdoch, C., Sharma, P., Williams, D., Webb, S. & Bearon, R. (2020). Multiscale modelling of drug transport and metabolism in liver spheroids. Interface Focus, 10(2). doi:10.1098/rsfs.2019.0041

[2] Scott, M., Zychaluk, K. & Bearon, R. (2021) A mathematical framework for modelling 3D cell motility; applications to Glioblastoma cell migration. Mathematical Medicine and Biology, 38(3) doi.org/10.1093/imammb/dqab009

Contact: Dr Geertje van Keulen & Dr Noemi Picco (Email: g.van.keulen@swansea.ac.uk) - Telephone: Noemi.Picco@swansea.ac.uk

Website: https://biomaths.swansea.ac.uk/

Event created by: g.van.keulen